Targetting  Nucleotide Excision Repair and  Pentose Phosphate Pathway for Cancer Treatments 

Along with the target of the pathways causing cancer and hampering the cancer treatment, we design and synthesize the chemical compounds in our lab. In order to improve cisplatin treatment, we have concentrated on the discovery of novel drugs that inhibit nucleotide excision repair and pentose phosphate pathways proteins through virtual screening and molecular dynamic simulations methods and investigate the efficiency of the designed and synthesized compounds using in vivo and in vitro experiments. 

Sancar, A. (2016). Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture). Angewandte Chemie International Edition, 55(30), 8502–8527.

Nucleotide excision repair is a mechanism that repair UV and cisplatin-induced DNA damage. In 2016, we have discovered the plant nucleotide excision repair mechanism in Sancar Lab. Our research group also focuses on the discovery of UV-induced DNA damage's repair mechanism in eukaryotic organisms, aiming to reveal the relationship between the repair mechanism and different pathways. 

 

Nucleotide Excision Repair Mechanism

 

Recent Publications

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Synthesis of novel 1,2,3 triazole derivatives and assessment of their potential cholinesterases, glutathione S-transferase enzymes inhibitory properties: An in vitro and in silico study

Selected Publications

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Nucleotide excision repair by dual incisions in plants

 
 

Project Title: Development of new indoleamide chemosensitizer drugs by targeting nucleotide excision repair mechanism to enhance the efficiency of platinum-based chemotherapy agents on cancer treatment. 

Project Manager: Muhammet Karaman, Ph.D.

Funding Agency: Health Institutes of Turkey (TÜSEB)

Grant Type: Innovative Drug R&D

Total Cost: 984. 899,40 ₺

Start/End: 2021/

Project Title: Synthesis of Schiff Base Derivatives and detection of effect on Pentose Phosphate Pathway. 

Project Manager: Muhammet Karaman, Ph.D.

Funding Agency: The Scientific and Technological Research Council of Turkey (TÜBİTAK) and Kilis 7 Aralik University, Scientific Research Unit (BAP).

Grant Type: Innovative Drug R&D 

Total Cost: 45.000,00 ₺ (TÜBİTAK) 22.000,00 ₺ (BAP)

Start/End: 2020/

Project Title: Identification of the Effects of Anti-Arrhythmic Drugs on Human Glucose 6-Phosphate Dehydrogenase Enzyme and revelation of Their Inhibition Mechanism. 

Project Manager: Muhammet Karaman, Ph.D.

Funding Agency: Scientific Research Unit (BAP), Kilis 7 Aralik University

Grant Type: Graduate Project 

Total Cost: 20.000,00 ₺

Start/End: 2019/2020

Project Title: Investigation of the Effects of New Naphthylamide Derivatives on the Glutathione Reductase Enzyme Activity Isolated from Human Erythrocyte.

Project Manager: Muhammet Karaman, Ph.D.

Funding Agency: Scientific Research Unit (BAP), Kilis 7 Aralik University

Grant Type: Innovative Drug R&D

Total Cost: 20. 000,00 ₺

Start/End: 2017/2019

 
 

We welcome people from several backgrounds: Chemistry, Biochemistry, Molecular biology, and Pharmacy to our lab. We are looking for enthusiastic and collaborative individuals to join our lab who are interested to do innovative and translational work. If you are interested in joining our team, please click to Join us botton.

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Muhammet Karaman

Assistant Professor

Head of Karaman Research Group

Research interests:
Computational methods in biochemistry, Targeted cancer therapy, DNA repair mechanisms

​Background:
B.Sc        Ataturk University, Chemistry

M.Sc       Erciyes University, Biochemistry

Ph.D.     Ataturk University, Biochemistry
                 Advisor    Mehmet Ciftci


Visiting  Researcher    University of North Carolina At Chapel Hill, Biophysics and Biochemistry
                                               Advisor Aziz Sancar

Halide Sedef Karaman

Ph.D.

Co-Pirincipal Investigator

Research interests:
Structural/ligand-based drug design, Organic Synthesis, Asymmetric synthesis, Targeted cancer therapy

​Background:
B.Sc        Ataturk University, Chemistry

M.Sc       Ataturk University, Chemistry

Ph.D. Ataturk University, Biochemistry
                Advisor    Hamdullah Kilic

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Fatma Yapici

Graduate Student

Research Fellow

Research interests:
Cancer immunotherapy, CRISPR, Targeted cancer therapy

​Background:
B.Sc        Kilis 7 Aralik University, Molecular Biology and Genetics

Melisa Seval

Graduate Student

Research interests:
Enzyme Kinetics

​Background:
B.Sc        Kilis 7 Aralik University, Molecular Biology and Genetics

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Kağan Karaman

Youngest Member​

​Background: Karaman Family

Interests: Toys

 

Gokce Kizilbay

Research interests:
Enzyme Kinetics

​Background:
B.Sc        Kilis 7 Aralik University, Molecular Biology and Genetics

M.Sc       Kilis 7 Aralik University, Molecular Biology and Genetics

                Advisor Muhammet Karaman

Next career:

Tahsin Huner

Research interests:
Enzyme Kinetics

​Background:
B.Sc        Kilis 7 Aralik University, Molecular Biology and Genetics

Next career:

Rümeysa Berçin

Research interests:
Enzyme Kinetics

​Background:
B.Sc        Kilis 7 Aralik University, Molecular Biology and Genetics

Next career:

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Leyla Banısarı

Research interests:
Enzyme Kinetics

​Background:
B.Sc        Kilis 7 Aralik University, Molecular Biology and Genetics

Next career:

 

Our novel drug design project for cancer treatment  is in the national press 

Dr. Muhammet Karaman spoke to TRT Çukurova radio about the drug they will develop for cancer treatment.

Click to listen
 
 
 
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AZİZ SANCAR

DNA Repair and Circadian Rhythm

University of North Carolina at Chapel Hill

Başarılı-Akademisyenler-Ödüllendirildi-5

MEHMET ÇİFTCİ

Enzyme Kinetics

Bingol University

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İLHAMİ GÜLÇİN

Enzyme Kinetics

Atatürk University

King Saud University

 

Karaman Research Group-2020

 

Karaman Research Group-2019

 

Before Karaman Research Group

 
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Muhammet Karaman Ph.D.

Pirincipal Investigator

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Office

Kilis 7 Aralik University, Faculty of Art and Science, Department of  Molecular Biology and Genetics

Kilis

Phone: +90 348 814 2666

External: 1537

Laboratory 

Kilis 7 Aralik University, Advanced Technology Application and Research Center, Chemistry 1 Laboratory

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