Targetting Nucleotide Excision Repair and Pentose Phosphate Pathway for Cancer Treatments
Along with the target of the pathways causing cancer and hampering the cancer treatment, we design and synthesize the chemical compounds in our lab. In order to improve cisplatin treatment, we have concentrated on the discovery of novel drugs that inhibit nucleotide excision repair and pentose phosphate pathways proteins through virtual screening and molecular dynamic simulations methods and investigate the efficiency of the designed and synthesized compounds using in vivo and in vitro experiments.
Sancar, A. (2016). Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture). Angewandte Chemie International Edition, 55(30), 8502–8527.
Nucleotide excision repair is a mechanism that repair UV and cisplatin-induced DNA damage. In 2016, we have discovered the plant nucleotide excision repair mechanism in Sancar Lab. Our research group also focuses on the discovery of UV-induced DNA damage's repair mechanism in eukaryotic organisms, aiming to reveal the relationship between the repair mechanism and different pathways.
Nucleotide Excision Repair Mechanism
Recent Publications
Selected Publications
We welcome people from several backgrounds: Chemistry, Biochemistry, Molecular biology, and Pharmacy to our lab. We are looking for enthusiastic and collaborative individuals to join our lab who are interested to do innovative and translational work. If you are interested in joining our team, please click to Join us botton.
Muhammet Karaman
Assistant Professor
Head of Karaman Research Group
Research interests:
Computational methods in biochemistry, Targeted cancer therapy, DNA repair mechanisms
Background:
B.Sc Ataturk University, Chemistry
M.Sc Erciyes University, Biochemistry
Ph.D. Ataturk University, Biochemistry
Advisor Mehmet Ciftci
Visiting Researcher University of North Carolina At Chapel Hill, Biophysics and Biochemistry
Advisor Aziz Sancar
Halide Sedef Karaman
Ph.D.
Co-Pirincipal Investigator
Research interests:
Structural/ligand-based drug design, Organic Synthesis, Asymmetric synthesis, Targeted cancer therapy
Background:
B.Sc Ataturk University, Chemistry
M.Sc Ataturk University, Chemistry
Ph.D. Ataturk University, Biochemistry
Advisor Hamdullah Kilic
Fatma Yapici
Graduate Student
Research Fellow
Research interests:
Cancer immunotherapy, CRISPR, Targeted cancer therapy
Background:
B.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
Melisa Seval
Graduate Student
Research interests:
Enzyme Kinetics
Background:
B.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
Gokce Kizilbay
Research interests:
Enzyme Kinetics
Background:
B.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
M.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
Advisor Muhammet Karaman
Next career:
Tahsin Huner
Research interests:
Enzyme Kinetics
Background:
B.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
Next career:
Rümeysa Berçin
Research interests:
Enzyme Kinetics
Background:
B.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
Next career:
Leyla Banısarı
Research interests:
Enzyme Kinetics
Background:
B.Sc Kilis 7 Aralik University, Molecular Biology and Genetics
Next career:
Our novel drug design project for cancer treatment is in the national press
Dr. Muhammet Karaman spoke to TRT Çukurova radio about the drug they will develop for cancer treatment.
Karaman Research Group-2020
Karaman Research Group-2019
Before Karaman Research Group
Office
Kilis 7 Aralik University, Faculty of Art and Science, Department of Molecular Biology and Genetics
Kilis
Phone: +90 348 814 2666
External: 1537
Laboratory
Kilis 7 Aralik University, Advanced Technology Application and Research Center, Chemistry 1 Laboratory
