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Muhammet Karaman gave a speech for Career Stalking'22 organized by Genç IVEK Foundation.

Gebze Teknik Üniversitesi Talk

Dr. Muhammet Karaman gave a talk

at Gebze Technical University

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We are a member of COST Action CA20121

Image by Fringer Cat

Dr. Muhammet Karaman spoke to TRT Çukurova radio about the drug they will develop for cancer treatment.

Victory Award in Science

Our publication was awarded 2nd place  in Victory Award in Science - 2021

News about TÜSEB project

Our novel drug design project for cancer treatment  is in the national press 

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Targetting  Nucleotide Excision Repair for Cancer Treatments 

Targetting  Nucleotide Excision Repair for Cancer Treatments 

Along with the target of the pathways causing cancer and hampering cancer treatment, we design and synthesize the chemical compounds in our lab. In order to improve cisplatin treatment, we have concentrated on the discovery of novel drugs that inhibit nucleotide excision repair proteins through virtual screening and molecular dynamic simulations methods and investigate the efficiency of the designed and synthesized compounds using in vivo and in vitro experiments. 

Mechanism of Targetting  Nucleotide Excision Repair from Nobrl Lecture of Aziz Sancar.  

Sancar, A. (2016). Mechanisms of DNA Repair by Photolyase and Excision Nuclease (Nobel Lecture). Angewandte Chemie International Edition, 55(30), 8502–8527.

Nucleotide Excision Repair Mechanism

Nucleotide Excision Repair Mechanism

Nucleotide excision repair is a mechanism that repair UV and cisplatin-induced DNA damage. In 2016, we have discovered the plant nucleotide excision repair mechanism in Sancar Lab. Our research group also focuses on the discovery of UV-induced DNA damage's repair mechanism in eukaryotic organisms, aiming to reveal the relationship between the repair mechanism and different pathways. 

Nucleotide excision repair by dual incisions in plants
Targetting Pentose Phosphate Pathway for Cancer Treatments 

Targetting Pentose Phosphate Pathway for Cancer Treatments 

The pentose phosphate pathway (PPP) is an important target for cancer treatment due to it plays a key role in biosynthesis and DNA synthesis which is the main target for chemotherapeutic drugs such as cisplatin and anthracycline. Inhibition of activity of glucose-6 phosphate dehydrogenase which is the first and checkpoint enzyme for the pathway cause slow down or destroys the growth of cancer cells. We are designing potential G6PD inhibitors for the blocking of PPP. 

Targetting Pentose Phosphate Pathway for Cancer Treatments 
 

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